Drugs Commonly Used in Clinical Trials
Taking Tramadol Hydrochloride or TCA as it is commonly known by its generic name, can produce several different effects depending on its concentrations in the body. At higher doses, it can be a powerful analgesic. At lower doses, it can act as a mild laxative. It has also been used to treat moderate to severe constipation and may help to relieve diarrhea associated with pregnancy.
Although it can provide relief from acute and chronic pain, and other gastrointestinal disorders, there are some serious side effects from taking it. First, users can experience allergic reactions to tramadol hydrochloride. The exact reaction is unpredictable but can include swelling of the throat, mouth, lips, and tongue, nausea, vomiting, and dizziness. Other symptoms include constipation, fatigue, sweating, changes in blood pressure, and changes in mental alertness. In some cases, overdose can also occur. If this occurs, seek emergency medical attention immediately.
Tramadol Hydrochloride Side Effects
Because it produces rapid and intense pain, tramadol hydrochloride should not be used by any person who is pregnant or breastfeeding. This product should also not be used by diabetics or those who have liver problems. When taken with prescription medications, it can lead to the elevation of calcium levels in the blood. This can result in dangerous side effects such as a rapid onset of kidney failure. Therefore, if you are a patient of prescription medication, you should avoid using these medications while taking tramadol hydrochloride.
In addition, taking tramadol as a component of a prescription medication can be dangerous. The dosage should be prescribed in accordance with the needs of your symptoms. If you experience an adequate level of relief with the product, it is generally considered acceptable to use it as a stand-alone medication, even without a doctor’s prescription. However, if you experience severe pain, you should only use it under the supervision of a doctor. If you are on any other medication, you should avoid using tramadol or consult your doctor before taking it.
Cytochrome P-2 enzyme has been found to be critical in the formation and release of prostaglandins, particularly the more-well-known (progesterone), and adrenocorticotrophic hormone (ACTH) in the body. Many of these hormones are important for normal physiological function. It is not known whether tramadol has any effect on the production of these hormones in the body. There is some evidence that it may increase cyp2d6 activity in the liver.
Some clinical studies have shown that tramadol does not change the expression of cyp2d6 protein in the liver, nor does it affect its protein binding activity. These results were found after a week of daily dose of tramadol in healthy men. It was also found that there was no significant change in plasma cortisol, nor did there appear to be an effect on the binding of this protein to the insulin receptor. The lack of effect on cyp2d6 activity and its relationship to insulin indicate that there is no significant physiological function to be affected by the daily intake of tramadol.
Is Tramadol Addictive
There are several potential adverse effects of tramadol. In high doses, it can cause serious liver damage. This is particularly worrisome when taking into account that the liver is the largest detoxifying organ in the body. The damage caused by tramadol may also lead to the development of kidney disease. The risk of kidney failure can be increased in people already suffering from another type of kidney disease such as dialysis. In a report by the FDA, lamotrigine was deemed to be “implicated” in the development of kidney failure in patients taking antisychopramine (clomipramine) for the treatment of depression.
Although the long-term effects of tramadol are not yet known, it is important to note that the doses of the drug that causes the least side effects are the ones used in combination with 1s,2s, and rasagunans. As an example, a patient taking four separate doses of tramadol, the antisychopramine, and the mood stabilizer could experience only mild nausea, constipation, and increased appetite. However, a patient taking two tramadol products, one containing the selective serotonin reuptake inhibitor (SSRI), and one containing the tricyclic antidepressant (TCA) in conjunction, could experience severe side effects such as insomnia, decreased libido, and anxiety.